Screening & Selection of Microorganisms or Enzymes
IMEnz provides access to unique enzyme libraries and conducts the screening of these libraries for the selection and identification of enzymes with desired or novel properties.Libraries of industrial enzymes, including proteases, chitinases, esterases, lipases and sugar-modifying enzymes are available.
One library contains more than 350 protease variants that vary in stability, pH optimum, substrate specificity, metal ion dependence, and absolute activity. They can be active both in aqueous and in organic environments. This particular class of proteases has been shown to be applicable in many kinds of bioconversion reactions, as diverse as hydrolysis and synthesis. The stereoselectivity of transformations obtained by biocatalysts makes them extremely powerful for chiral resolution applications.
Protein Valorization
Microorganisms
IMEnz’ micro-organism collections are based on (more than 2000) strains isolated from very diverse and or extreme environments, such as polluted soils, locations where lignocellulosic biomass was abundant and degraded, but also gut-flora of exotic animals.
Related to the different collections IMEnz Bioengineering BV offers the following services:
- development of application-oriented screening procedures
- screening of the libraries for specific biotransformations
- identification of biocatalysts involved
- isolation, production and upscaling of identified, interesting variants
- further improvement of selected biocatalysts by means of strain improvement, protein engineering and or directed evolution
- assistance in obtaining exclusive rights to use selected variants
- assistance in search and operation of new libraries
Development of Green Biocatalytic Processes
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Screening & Selection of Microorganisms or Enzymes
IMEnz provides access to unique enzyme libraries and conducts the screening of these libraries for the selection and identification of enzymes with desired or novel properties. Libraries of industrial enzymes, including proteases, chitinases, esterases, lipases and sugar-modifying enzymes are available.
One library contains more than 350 protease variants that vary in stability, pH optimum, substrate specificity, metal ion dependence, and absolute activity. They can be active both in aqueous and in organic environments. This particular class of proteases has been shown to be applicable in many kinds of bioconversion reactions, as diverse as hydrolysis and synthesis. The stereoselectivity of transformations obtained by biocatalysts makes them extremely powerful for chiral resolution applications.
Protein Valorization
IMEnz has expertise in protein valorisation according to our strategy to hydrolyse proteins and screen for functionalities, such as peptides that increase growth (rate) during fermentation or peptides with anti-microbial activity. Many protein sources have been studied, among which plant -, algae -, and animal proteins.
IMEnz has developed several different products via this strategy: tailor made fermentation nutrients, resulting in improvement of customer related industrial fermentation processes, as well as numerous natural anti-microbials that inhibit either specific (pathogenic) species or entire groups of microorganisms. It is our standard approach to design the process such that it is suited for large scale industrial applications.
Microorganisms
In addition, IMEnz’ micro-organism collections are based on (more than 2000) strains isolated from very diverse and or extreme environments, such as polluted soils, locations where lignocellulosic biomass was abundant and degraded, but also gut-flora of exotic animals.
Related to the different collections IMEnz Bioengineering BV offers the following services:
- development of application-oriented screening procedures
- screening of the libraries for specific biotransformations
- identification of biocatalysts involved
- isolation, production and upscaling of identified, interesting variants
- further improvement of selected biocatalysts by means of strain improvement, protein engineering and or directed evolution
- assistance in obtaining exclusive rights to use selected variants
- assistance in search and operation of new libraries
Development of Green Biocatalytic Processes
Also, IMEnz can explore her strain collections to find a microorganism suited for the bioproduction of a desired biochemical or intermediate. Specific micro organisms that can do the job or isolated enzymes that catalyze a specific reaction step in a chemical synthesis process can be screened for. In our collection we have found natural hosts that produce optically pure enantiomers of various biochemicals.